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阐明中药科学内涵推进中药现代化与创新药物研究进程
引用本文:姚新生|叶文才|栗原博. 阐明中药科学内涵推进中药现代化与创新药物研究进程[J]. 化学进展, 2009, 21(1): 2-13
作者姓名:姚新生|叶文才|栗原博
作者单位:沈阳药科大学,沈阳110016;暨南大学药学院,广州510632;暨南大学药学院,广州,510632
摘    要:众所周知,中药对中华民族的繁衍昌盛发挥了不可磨灭的功绩。但是,作为经验医学,中药具有与生俱来的不足,诸如:缺乏采用循证医学原则提供的现代临床试验数据和结果;作用机理和作用物质尚不清楚;缺乏严格、科学的质量监控标准和方法。因此,难以保证达到作为药物所必须具备的“安全、有效、稳定、可控”的质量要求。这个问题如果不能妥善解决,不仅难于保证国人对疾病防治的需求,更难走向国际医药主流社会。通过多年的思考与实践,为揭示中药的科学内涵,推动中药现代化和创新药物研究,我们提出了一些新的研究思路和方法。

关 键 词:经验医学  循证医学  中药现代化和国际化  中药质量监控
收稿时间:2008-11-27

Reveal the Scientific Connotation of TCM for Promoting Its Modernization and Innovative Drug Research Process
Yao Xinsheng|Ye Wencai|Hiroshi Kurihara. Reveal the Scientific Connotation of TCM for Promoting Its Modernization and Innovative Drug Research Process[J]. Progress in Chemistry, 2009, 21(1): 2-13
Authors:Yao Xinsheng|Ye Wencai|Hiroshi Kurihara
Affiliation:(1. Shenyang Pharmaceutical University, Shenyang 110016, China|2. College of Pharmacy, Jinan University, Guangzhou 510632, China)
Abstract:It is well known that traditional Chinese medicine(TCM) has played an indelible contribution for the prosperity of China. However, as one of the experiential medicine, traditional Chinese medicine has also inherent weaknesses and deficiencies, such as lack of modern clinical trial data and results provided by evidence-based medicine principles, mechanism of action and the working substances not known yet, lack of strict and scientific quality control standards and methods. So it is difficult to guarantee a drug to reach the "safe, effective, stable and controllable" quality requirements. If these problems can not be seriously and satisfactory resolved, it is not only difficult to ensure the demands of people for treatment and prevention of diseases, and even harder to access the international mainstream medical community. After years of thinking and practicing, we propose some new ideas and methods to reveal the scientific connotation of TCM for promoting TCM modernization and innovation process.
Keywords:experimental medicine  evidence based medicine(EBM)  modernization and internationalization of traditional Chinese medicine  quality control of traditional Chinese medicine
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