Synthesis of diethylamides of α-diethylaminocarboxylic acids using α-trichloromethylcarbinols and their acetates under phase-transfer catalysis conditions

Conclusions Trichloromethyicarbinols and their acetates react with diethylamine under phase-transfer catalysis conditions to give diethylamides of -diethylaminocarboxylic acids. The same products are formed in the reaction of aldehyde acylals with chloroform and diethylamine in the 50% aqueous NaOH-BTEAC phase-transfer catalytic system.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1190–1192, May, 1986.