| 1-氟代糖在化学-酶法合成糖类中的应用 |
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| 引用本文： | 卢丽丽,肖敏,赵晗,王鹏,钱新民.1-氟代糖在化学-酶法合成糖类中的应用[J].有机化学,2006,26(12):1631-1639. |
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| 作者姓名： | 卢丽丽 肖敏 赵晗 王鹏 钱新民 |
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| 作者单位： | 山东大学微生物技术国家重点实验室,济南,250100 |
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| 基金项目： | 国家自然科学基金(No.30170008)，国家“十五”攻关计划(No.2004BA713B04-06)资助项目. |
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| 摘 要： | 化学-酶法合成糖类具有立体选择性和区域选择性, 逐渐成为糖类合成的主流. 1-氟代糖作为糖基供体应用于化学-酶法合成反应, 显示出越来越重要的作用, 综述了1-氟代糖在糖基转移酶和糖苷酶催化的糖类合成中的应用.
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| 关 键 词： | 1-氟代糖 化学-酶法合成 糖类 糖基转移酶 糖苷酶 |
| 收稿时间： | 01 11 2006 12:00AM |
| 修稿时间： | 04 9 2006 12:00AM |
1-Glycosyl Fluorides in Carbohydrate Synthesis by Chemoenzymatic Methods |
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| LU Li-Li,XIAO Min,ZHAO Han,WANG Peng,QIAN Xin-Min.1-Glycosyl Fluorides in Carbohydrate Synthesis by Chemoenzymatic Methods[J].Chinese Journal of Organic Chemistry,2006,26(12):1631-1639. |
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| Authors: | LU Li-Li XIAO Min ZHAO Han WANG Peng QIAN Xin-Min |
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| Institution: | State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100 |
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| Abstract: | Chemoenzymatic methods have advantages over classical chemical methods in carbohydrate synthesis owing to stereoselectivity and regioselectivity. 1-Glycosyl fluorides, which act as glycosyl donors, are becoming increasingly important in the chemoenzymatic reactions. The application of 1-glycosyl fluo- rides in the glycosyl transferase and glycosidase-catalysed carbohydrate synthesis is reviewed in this paper. |
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| Keywords: | 1-glycosyl fluoride chemoenzymatic synthesis carbohydrate glycosyl transferase glycosidase |
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