1, 4-Benzodiazepines and their cyclic homologs and analogs

The physicochemical and pharmacological properties of compounds of eight series of derivatives of 1,2-dihydro-3H-1,4-benzodiazepine have been considered. A marked relationship between the half-neutralization potentials, half-wave potentials of polarographic reduction, and the dipole moments of the compounds with Hammett's constants of the substituents in position 7 has been found. In all the series studied, a tendency is observed to an increase in the physiological activity of the compounds with an increase in the electron-accepting nature of the substituents in position 7.For Communication XI, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1558–1565, November, 1973.