Reversed approach to S-farnesylation and S-palmitoylation: application to an efficient synthesis of the C-terminus of lipidated human N-ras hexapeptide |
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Authors: | Pachamuthu Kandasamy Zhu Xiangming Schmidt Richard R |
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Affiliation: | Fachbereich Chemie, Universit?t Konstanz, Fach M 725, D-78457 Konstanz, Germany. |
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Abstract: | [reaction: see text] A general reversed approach is described to synthesize S-palmitoylated and S-farnesylated peptides via S(N)2 displacement of bromide by reaction of a thiol group containing lipid as nucleophile with bromoalanine-containing peptides as electrophile. By employing this approach, lipidated peptides, including characteristic partial structures of human Ras peptides, were synthesized in good yields. This method gives access to farnesylated, palmitoylated, and doubly lipidated peptides. |
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