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Biocompatible nanoparticles and gadolinium complexes for MRI applications |
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| Authors: | Thomas Courant Gaelle V. Roullin Cyril Cadiou Maité Callewaert Marie C. Andry Christophe Portefaix Christine Hoeffel Marie C. de Goltstein Marc Port Sophie Laurent Luce Vander Elst Robert N. Muller Michael Molinari Françoise Chuburu |
| Affiliation: | 1. Institut de chimie moléculaire de Reims, CNRS UMR 7312, UFR Pharmacie Reims, 51, rue Cognacq-Jay, 51100 Reims, France;2. Institut de chimie moléculaire de Reims, CNRS UMR 7312, UFR des sciences exactes et naturelles, bâtiment 18, Europol’Agro, BP 1039, 51687 Reims cedex 2, France;3. CHU de Reims, Service de radiologie, hôpital Maison-Blanche, 45, rue Cognacq-Jay, 51092 Reims cedex, France;4. GUERBET, BP57400, 95943 Roissy-Charles-de-Gaulle cedex, France;5. NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons, 19, avenue Maistriau, 7000 Mons, Belgium;6. Center for Microscopy and Molecular Imaging, 8, rue Adrienne-Bolland, 6041 Charleroi, Belgium;7. Laboratoire de recherche en nanosciences, UFR des Sciences, université de Reims–Champagne-Ardenne, 21, rue Clément-Ader, 51685 Reims cedex 2, France |
| Abstract: | Performances of double-emulsion techniques (W/O/W and W/O/O) and ionotropic gelation process were compared to achieve encapsulation of gadolinium MRI contrast agents (GdCAs) into biocompatible polymeric nanoparticles (NPs) with high Gd-loadings. The better approach proved to be ionotropic gelation with H[Gd(DOTA)] as GdCA. Relaxometry evaluation of H[Gd(DOTA)]?NPs efficiency demonstrated that incorporation of H[Gd(DOTA)] inside an hydrogel matrix highly improved H[Gd(DOTA)] relaxivity. Particle efficacy as MR contrast agents was further demonstrated on a 3 T clinical imager: a significant improvement of T1- and T2- MR signals was obtained at doses much lower than the currently used. |
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