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Biocompatible nanoparticles and gadolinium complexes for MRI applications |
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| Authors: | Thomas Courant Gaelle V Roullin Cyril Cadiou Maité Callewaert Marie C Andry Christophe Portefaix Christine Hoeffel Marie C de Goltstein Marc Port Sophie Laurent Luce Vander Elst Robert N Muller Michael Molinari Françoise Chuburu |
| Institution: | 1. Institut de chimie moléculaire de Reims, CNRS UMR 7312, UFR Pharmacie Reims, 51, rue Cognacq-Jay, 51100 Reims, France;2. Institut de chimie moléculaire de Reims, CNRS UMR 7312, UFR des sciences exactes et naturelles, bâtiment 18, Europol’Agro, BP 1039, 51687 Reims cedex 2, France;3. CHU de Reims, Service de radiologie, hôpital Maison-Blanche, 45, rue Cognacq-Jay, 51092 Reims cedex, France;4. GUERBET, BP57400, 95943 Roissy-Charles-de-Gaulle cedex, France;5. NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons, 19, avenue Maistriau, 7000 Mons, Belgium;6. Center for Microscopy and Molecular Imaging, 8, rue Adrienne-Bolland, 6041 Charleroi, Belgium;7. Laboratoire de recherche en nanosciences, UFR des Sciences, université de Reims–Champagne-Ardenne, 21, rue Clément-Ader, 51685 Reims cedex 2, France |
| Abstract: | Performances of double-emulsion techniques (W/O/W and W/O/O) and ionotropic gelation process were compared to achieve encapsulation of gadolinium MRI contrast agents (GdCAs) into biocompatible polymeric nanoparticles (NPs) with high Gd-loadings. The better approach proved to be ionotropic gelation with HGd(DOTA)] as GdCA. Relaxometry evaluation of HGd(DOTA)]?NPs efficiency demonstrated that incorporation of HGd(DOTA)] inside an hydrogel matrix highly improved HGd(DOTA)] relaxivity. Particle efficacy as MR contrast agents was further demonstrated on a 3 T clinical imager: a significant improvement of T1- and T2- MR signals was obtained at doses much lower than the currently used. |
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