Amberlyst A21: A reusable solid catalyst for green synthesis of pyran annulated heterocycles at room temperature |
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Authors: | Manisha Bihani Pranjal P. Bora Ghanashyam Bez Hassan Askari |
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Affiliation: | Department of Chemistry, North Eastern Hill University, 793022 Shillong, India |
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Abstract: | Amberlyst A21, a neutral ion-exchange resin and a solid base, can catalyze the three-component reaction of aldehyde and malononitrile with various active methylene compounds at room temperature to synthesize a range of pharmaceutically important pyran annulated heterocycles. Use of the solid base could generate a highly green protocol by eliminating chromatographic purification that involves hazardous organic solvents, and facilitate easy recovery and reusability of the catalyst. |
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