Direct alkenylation of non-aromatic enamides via palladium-catalyzed oxidative coupling: Synthetic developments and applications |
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| Authors: | Nicolas Gigant Laëtitia Chausset-Boissarie Romain Rey-Rodriguez Isabelle Gillaizeau |
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| Affiliation: | Institut de chimie organique et analytique, Université d’Orléans, UMR 7311 CNRS, rue de Chartres, 45067 Orléans cedex 2, France |
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| Abstract: | Direct C(3) alkenylation of non-aromatic enamides through palladium(II)-catalyzed Fujiwara–Moritani cross-coupling was developed. The reaction scope includes a range of cyclic enamides as well as activated alkenes. The utility of this methodology is illustrated by the synthesis of octa- or tetrahydroquinoline cores obtained from conjugated enamides via Diels–Alder cycloaddition. |
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