Synthesis and pharmacological activities of some dibenzopyrazolocinnolines and dibenzopyridazinoquinoxalines

Derivatives of three new classes of heterocyclic compounds have been synthesized. The first class comprises the synthesis of pyrimidino- and imidazolopyrazolopyridazine using 11 H-dibenzof,h]pyrazolo3,4-c]-cinnoline-13-amine. The second class involves the synthesis of triazine derivatives using 11 H-dibenzo-f,h]pyrazolo3,4-c]cinnoline-13-diazonium chloride. The third class deals with the synthesis of polycyclic compounds using dibenzof,h]pyridazino4,5-b]quinoxaline-10,13-diamine. The pharmacological screening has shown that several of these compounds have good antiparkinsonian activities comparable to Benzatropine. The detailed synthesis, spectroscopic data, and pharmacological properties are reported.