Unexpected synthesis of indolo[1,2-c]quinazolines by a sequential Ugi 4CC-Staudinger-aza-Wittig-nucleophilic addition reaction |
| |
Authors: | He Ping Nie Yi-Bo Wu Jing Ding Ming-Wu |
| |
Institution: | Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, 430079, PR China. |
| |
Abstract: | A new sequential Ugi-Staudinger-aza-Wittig-nucleophilic addition reaction was developed to construct indolo1,2-c]quinazoline derivatives, starting from the easily accessible 2-azidobenzaldehyde, carboxylic acid, 2-acylaniline and isocyanide. It is noteworthy that this is the first report of the cyclization of the Ugi adduct to give a dihydroindole ring system with two quaternary carbon centers, via the nucleophilic addition reaction of the methine group to the carbonyl group. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|