Near-IR single fluorophore quenching system based on phthalocyanine (Pc) aggregation and its application for monitoring inhibitor/activator action on a therapeutic target: L1-EN |
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| Authors: | Nesterova Irina V Bennett Cecily A Erdem S Sibel Hammer Robert P Deininger Prescott L Soper Steven A |
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| Institution: | Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA. |
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| Abstract: | Controlled H-aggregation of single Pc-labeled oligonucleotides is utilized as a fluorescence quenching system to discern changes in enzyme activity for the discovery of inhibitors for Long Interspersed Element 1 endonuclease (L1-EN), which is involved in genome instability and implicated in many different diseases. |
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