Nanofibers of silk fibroin controlled by the crystallization of polyethylene glycol in frozen solution |
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Authors: | Cong-heng Chen Juan Zhao Zhou Yang Qing Sun Ping Zhou |
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Institution: | State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China |
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Abstract: | The conformation of silk flbroin (SF) frozen with polyethylene glycol (PEG) at a molecular weight from 2 kDa to 20 kDa and a mass ratio of PEG:SF from 1:5 to 10:1 was studied by spectral and microscopic methods.It is found that the conformation transition of SF from random coil to β-sheet could be induced by the stress resulting from PEG crystallization at-20 C,and greatly depended on the cooling rate,PEG:SF mass ratio and PEG molecular weight.These findings provide a new method for the preparation of desired SF nanofibers. |
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Keywords: | Silk fibroin Polyethylene glycol Freezing Phase separation Crystallization |
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