Condensed pyrimidine,pyrazine, and pyridine systems.

A simple method was develeped for the synthesis of n₁- and N₃-alkyl- and N₁,N₃-dialkyl(aryl, alkyl)-5-chloroacetyl-6-aminouracil by reaction of 6-aminouracils with chloroacetyl chloride in monochloroacetic acid. 2,4,5-Trioxopyrrole[2,3-d]pyrimidines were obtained by the action of aqueous alkali on N₁alkyl-5-chloroacetyl-6-aminouracils and by the action of sodium ethoxide on N₃-alkyl- and N₁,N₃-dialkyl(aryl, alkyl)-5-chloroacetyl-6-aminouracils. When there is an alkyl substituent attached to the 3-N atom in 2,4,5-trioxopyrrolo[2,3-d]pyrimidines, the pyrrole ring readily opens up under the influence of alkali to give 5-hydroxyacetyl-6-amino uracils.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 537–540, April, 1978.