Synthesis of cytisine derivatives of coumarins |
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| Authors: | M. S. Frasinyuk V. I. Vinogradova S. P. Bondarenko V. P. Khilya |
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| Affiliation: | (1) Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, 02094, Ukraine, Kiev, ul. Murmanskaya, 1;(2) S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Uzbekistan, Tashkent;(3) Taras Shevchenko Kiev National University, 01033, Ukraine, Kiev, ul. Vladimirskaya, 64 |
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| Abstract: | New substituted 4-chloromethylcoumarins that were used as alkylating agents to modify cytisine were synthesized by Pechmann condensation. A series of 4-(12-cytisylmethyl)coumarins containing pharmacophores of the natural heterocycles coumarin and cytisine in a single molecule was prepared. The alkylation gave the best results if diisopropylethylamine was used as the base. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 485–488, September–October, 2007. |
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| Keywords: | cytisine 4-chloromethylcoumarin alkylation diisopropylethylamine |
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