Synthesis, characterization, and biological activities of some transition metal(II) complexes with the thiosemicarbazone derived from 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one |
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| Authors: | J Q Qu G C Sun L F Wang L Qu |
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| Institution: | (1) Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, P. R. China;(2) State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China;(3) Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, 750002, P. R. China |
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| Abstract: | A new 4-1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one thiosemicarbazone (HL) was synthesized derived from 4-1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one. Four transition metal(II) complexes of HL have been prepared. Elemental analysis, molar conductivity,
IR, UV, 1H NMR spectra, and TG-DTA have been used to characterize these complexes. The complexes have the general formula ML2, where M = Zn, Cu, Co, and Ni. The ligand and its complexes have been studied for their possible biological activity including
anti-inflammatory, antibacterial, and antitumour activity in vitro. |
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