Poorly water-soluble drug nanoparticles via an emulsion-freeze-drying approach

In this paper, we examine, by dissipative particle dynamics (DPD) simulation, the interactions between nanoparticles and block copolymer bilayer membranes. The bilayer has a hydrophobic core and hydrophilic head groups on both sides of the core. Nanoparticles without or with a grafted homopolymer are considered. For the conditions investigated, the single nanoparticles and small aggregates are located at the interfaces of the membrane, namely the interfaces between the hydrophilic domains of the membrane and the solvent as well as at the interface between the hydrophobic and hydrophilic domains of the membrane. The large aggregates are located in the hydrophilic domains. By increasing the length of the homopolymer grafted on the nanoparticles, the size of the aggregates in the membrane decreases. At relatively short DPD step times, the particles aggregate in the solvent. As the time increases, the single particles and aggregates penetrate into the membrane.