N-[4-(arylpiperazin-1-yl)butyl]bicyclo[2.2.1]hept-5-ene-endo-2,endo-3-dicarboximides and Their Epoxy Derivatives. Synthesis and affinity for 5-HT1a receptors |
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| Authors: | S. Yu. Makan D. I. Tsymbal S. G. Soboleva I. N. Tarabara L. I. Kas’yan S. A. Andronati |
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| Affiliation: | (1) Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, Lyustdorfskaya dor. 86, Odessa, 65080, Ukraine;(2) Mechnikov Odessa National University, Odessa, Ukraine;(3) Dnepropetrovsk National University, Dnepropetrovsk, Ukraine |
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| Abstract: | New ligands for 5-HT1A serotonin receptors, N-[4-(4-arylpiperazin-1-yl)butyl]bicyclo[2.2.1]hept-5-ene-endo-2,endo-3-dicarboximides and their epoxy derivatives, were synthesized, and their affinity for 5-HT1A receptors was estimated at 16.2 ± 2.0 to 0.60 ± 0.08 nM. Original Russian Text ? S.Yu. Makan, D.I. Tsymbal, S.G. Soboleva, I.N. Tarabara, L.I. Kas’yan, S.A. Andronati, 2009, published in Zhurnal Obshchei Khimii, 2009, Vol. 79, No. 2, pp. 303–307. |
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