4-硫醚基喹唑啉类化合物的合成及抑菌活性研究

以4-氯喹唑啉和巯基化合物为原料, 丙酮作溶剂, 碳酸钾作缚酸剂, 合成了7个新型4-硫醚基喹唑啉类化合物. 采用¹H NMR, ¹³C NMR, IR及元素分析对目标化合物的结构进行了表征. 生物活性测试表明, 化合物1d在50 μg•mL^－1 药剂浓度下对小麦赤霉病菌、辣椒枯萎病菌、苹果腐烂病菌的抑菌活性分别达到69.5%, 71.9%和70.8%, EC₅₀分别为25.88, 17.08和28.77 μg•mL^－1.

Synthesis and Antifungal Activity of 4-Thioquinazoline Compounds

Seven novel 4-thioquinazoline compounds were synthesized by the reaction of 4-chloroquinazoline with mercapto compounds in acetone using anhydrous K₂CO₃. The structures of the title compounds were characterized by elemental analyses, IR, ¹H NMR and ¹³C NMR spectra. The results of bioassay showed that compound 1d had good antifungal activity against Fusarium graminearum, Fusarium oxysporum and Cytospora mandshurica with respective inhibition rate of 69.5%, 71.9% and 70.8% at the concentration of 50 μg•mL^－1, and EC₅₀ of 1d was 25.88, 17.08 and 28.77 μg•mL^－1.