Combinatorial transition-metal catalysis: mixing monodentate ligands to control enantio-, diastereo-, and regioselectivity |
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Authors: | Reetz Manfred T |
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Affiliation: | Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim/Ruhr, Germany. reetz@mpi-muelheim.mpg.de |
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Abstract: | This review focuses on a new approach to combinatorial homogeneous transition-metal catalysis which goes beyond the traditional parallel preparation of modular ligands. It is based on the use of mixtures of monodentate ligands L(a) and L(b), which upon exposure to a transition metal (M) form not only the two homocombinations [ML(a)L(a)] and [ML(b)L(b)], but also the heterocombination [ML(a)L(b)]. If the latter is more reactive and selective than the homocombinations, an improved catalyst system is formed without the need to synthesize new ligands. Thus, the control of enantio,- diastereo-, and regioselectivity is possible. |
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Keywords: | asymmetric catalysis combinatorial chemistry nonlinear effects P ligands transition‐metal catalysis |
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