The identification of flunitrazepam and its metabolites in urines samples |
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| Authors: | HH van Rooij A Fakiera R Verrijk W Soudijn JP Weijers-Everhard |
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| Institution: | University of Amsterdam, Division of Pharmaceutical Chemistry, Plantage Muidergracht 24, 1018 TV Amsterdam The Netherlands;Laboratorium Jellinek Centrum, Sarphatistraat 75, 1018 EX Amsterdam The Netherlands |
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| Abstract: | A thin-layer chromatographic method with fluorescence detection is described for the identification of flunitrazepam and its metabolites in urine. The method is based on the hydrolysis and subsequent formation of acridine derivatives by cyclization in dimethylformamide and is selective for benzodiazepines with a 2-fluorophenyl group. The method is applicable to urine samples even after an oral dose of only 2 mg of flunitrazepam. Flunitrazepam and flurazepam consumption can be distinguished. |
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