A chloroquine membrane electrode with low detection limit |
| |
| Authors: | Vasile V. Coşofrţ Richard P. Buck |
| |
| Affiliation: | Institute of Chemical and Pharmaceutical Research Bucharest, 74351-Sos. Vitan 112, Bucharest-3 Romania;Department of Chemistry, University of North Carolina, Chapel Hill, NC 27514 U.S.A. |
| |
| Abstract: | A PVC membrane electrode for chloroquine [7-chloro-4-(4-diethylamine-1-methylbutylamino)-quinoline] based on a chloroquine/dinonylnaphthalene sulphonic acid ion-pair is described. The electrode shows near-Nernstian response in the 10?2–10?6 M range and a detection limit of 2 × 10?7 M. Its selectivity relative to various inorganic ions, amino acids, neurotransmitters, drugs, and some excipients is reported. Direct potentiometry is used to determine chloroquine in pharmaceutical preparations with good results. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
