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Flow-injection spectrophotometric determination of enalapril in pharmaceuticals with bromothymol blue
Authors:Toshhiro Kato
Affiliation:Research Laboratories, Nippon Merck-Banyu Co., 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02 Japan
Abstract:Enalapril (1.5–60 μ gl?1) in aqueous solution is extracted into dichloromethane as its ion-pair with bromothymol blue in an unsegmented flow system and quantified spectrophotometrically. Up to 80 samples h?1 can be processed, with r.s.d. of 1.0–3.4%. The degradation products of enalapril and excipients in the pharmaceutical dosage form do not interfere.
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