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| 微流控芯片测定盐酸地芬尼多片中盐酸地芬尼多 | |
| 引用本文： | 李永冲,易国斌,蔡自由,陈缵光.微流控芯片测定盐酸地芬尼多片中盐酸地芬尼多[J].广州化学,2011,36(2):1-6. |
| 作者姓名： | 李永冲 易国斌 蔡自由 陈缵光 |
| 作者单位： | 1. 广东工业大学轻工化工学院,广东广州,510090 2. 广东食品药品职业学院,广东广州,510520 3. 中山大学药学院,广东广州,510006 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 利用微流控芯片非接触电导检测法测定片剂中盐酸地芬尼多的含量.采用1 mmol/L HAc+2 mmol/L NaAc(pH 4.5)为缓冲溶液,0.2 mmol/L 十二烷基硫酸钠(SDS)为添加剂,在分离电压为2.20 kV,进样时间为10 s下,1 min内实现组分快速分离和检测.盐酸地芬尼多线性范围为5～160 ... |
| 关 键 词： | 微流控芯片 非接触电导检测 盐酸地芬尼多 测定 |
Determination of the Difenidol Hydrochloride in Its Tablets by Microfluidic Chip |
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| LI Yong-chong,YI Guo-bin,CAI Zi-you,CHEN Zuan-guang.Determination of the Difenidol Hydrochloride in Its Tablets by Microfluidic Chip[J].Guangzhou Chemistry,2011,36(2):1-6. | |
| Authors: | LI Yong-chong YI Guo-bin CAI Zi-you CHEN Zuan-guang |
| Institution: | 1.Faculty of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510090,China;2.Guangdong Food and Drug Vocational College,Guangzhou 510520,China;3.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China) |
| Abstract: | The difenidol hydrochloride in its tablets was determined by microfluidic chip with contactless conductivity detection with 1 mmol/L HAc+2 mmol/L NaAc(pH 4.5) as buffer solution,0.2 mmol/L SDS as additive.The difenidol hydrochloride was separated and detected in 1 min at the separation voltage of 2.20 kV and injection time 10s.The linear dependence of the concentration of difenidol hydrochloride ranged from 5 to 160 μg/mL(r=0.9994),with the detection limit of 2.0 μg/mL(S/N=3),the relative standard deviation(RSD) of 1.4% and the recoveries from 98.8% to 100.6%. |
| Keywords: | microfluidic chip contactless conductivity detection difenidol hydrochloride determination |
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