手性胺有机小分子不对称催化的研究进展

扼要综述了有机手性胺催化在过去十年中的发展,列举了具有代表性的活化模式(如仲胺催化的活化模式)、催化剂(如手性叔胺有机催化剂)和反应类型(如分子内Aldol环化反应,分子间Aldol缩合反应,Lewis酸活化羰基化合物机制,手性胺催化等),并提出了该领域新的研究方向.手性胺不对称催化在手性合成中具有广阔的应用前景.

Review on Studies of Asymmetrie Chiral Amines

This article briefly reviewed organic amine catalytic development in the past decade,lists the representative activation patterns,catalyst and reaction type,e.g.activation pattern of secondary amine catalytic,chiral tertiary amine organic catalyst,aldol reactions for ring synthesis,aldol condensation reaction,Lewis acid activation carbonyl compounds mechanism,chiral amine catalytic,and put forward the new research direction in and challenges in this field.