Palladium-catalyzed alpha-vinylation of carbonyl compounds |
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| Authors: | Huang Jinkun Bunel Emilio Faul Margaret M |
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| Institution: | Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. jhuang@amgen.com |
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| Abstract: | A mild, general, catalytic system for the alpha-vinylation of carbonyl compounds has been developed. By employing Pd(P(t)Bu(3))Br](2) as catalyst and LHMDS as base, vinyl bromides, vinyl triflates, and vinyl tosylates couple with 3-methyloxindole in satisfactory yields. The same catalytic system is extended to the alpha-vinylation of ketones and esters. |
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