Peptides adsorption on TiO2 and Au: Molecular organization investigated by NEXAFS, XPS and IR |
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Authors: | G. Iucci C. Battocchio R. Gambaretto F. Borgatti S. Monti |
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Affiliation: | a Department of Physics, University “Roma Tre”, Via della Vasca Navale 84, 00146 Rome, Italy b Department of Chemical Process Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy c TASC-CNR, SS14, Km 163.5, 34012 Trieste, Italy d IPCF-CNR, Via Moruzzi 1, 56124 Pisa, Italy |
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Abstract: | We present a spectroscopic study of the structure of two peptides deposited on Au and TiO2:- - PeptA, (EAK16-RGD) bringing the adhesive RGD sequence linked to EAK16;
- - PeptB, having RGD linked to a “scrambled” sequence of the EAK16 peptide.
Previously reported NEXAFS investigations on thin films of the self-assembling peptide EAK16 deposited on Au and TiO2, revealed molecular order and orientation for both substrates.IR spectra show a β-sheet conformation for PeptA and a random structure for PeptB. Angular-dependent NEXAFS measurements reveal an ordered structure with preferential molecular orientation only for PeptA. XPS analysis indicates that PeptA is adsorbed on TiO2 in a larger amount than PeptB. |
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Keywords: | XPS NEXAFS Self-assembling peptides |
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