Synthesis of oligosaccharides on soluble high-molecular-weight branched polymers in combination with purification by nanofiltration |
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| Authors: | Majumdar Debatosh Zhu Tong Boons Geert-Jan |
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| Affiliation: | Complex Carbohydrate Research Center, The University of Georgia, 220 Riverbend Road, Athens, Georgia, 30602-4712, USA. |
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| Abstract: | [structure: see text] An efficient approach for polymer-supported oligosaccharide synthesis is described whereby branched and high-molecular-weight PEG derivatives are used in combination with purification by nanofiltration. This methodology was applied to the preparation of a tetraglucoside and the tumor-associated antigen Le(x). |
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