A cis amide bond surrogate incorporating 1,2,4-triazole |
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| Authors: | Hitotsuyanagi Yukio Motegi Shuichi Fukaya Haruhiko Takeya Koichi |
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| Affiliation: | School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. |
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| Abstract: | A novel cis amide bond surrogate incorporating 1,2,4-triazole was designed and synthesized by the reaction of a thionotripeptide, formic hydrazide, and mercury(II) acetate. This method of surrogate formation was also applicable to a cyclic thionopeptide. |
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