Synthesis of 3-(1,5-diphenyl-3-pyrazolyl)aryl propanoates |
| |
| Authors: | William V. Murray Susan K. Hadden Michael P. Wachter |
| |
| Affiliation: | The R. W. Johnson Pharmaceutical Research Institute, P.O. Box 300, Route 202, Raritan, New Jersey 08869-0602 |
| |
| Abstract: | New procedures for the synthesis of 3-(1,5-diphenyl-3-pyrazolyl)aryl propanoates and related 2-(1,5-diphenyl-3-pyrazolyl)aryl propanoates from a common 3-hydroxymethylpyrazole intermediate are described. These new procedures include an improved method for carrying out pyridinium chlorochromate oxidations under ultrasonic conditions. These syntheses also utilize lithium triethylphosphonoacetate formed from n-butyllithium and triethylphosphonoacetate as a Wittig-Horner reagent to improve olefination yields. |
| |
| Keywords: | |
|
|
