Synthesis and antimalarial activity of a series of 2,4-diamino-6-[(N-alkylanilino)methyl]quinazolines |
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Authors: | Leslie M Werbel Edward F Elslager Linda S Newton |
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Institution: | Chemistry Department, Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan, 48105 |
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Abstract: | A series of 2,4-diamino-6-(N-alkylanilino)methyl]quinazolines were prepared by bromination of 2,4-dibenz-amido-6-methylquinazoline followed by treatment with secondary arylamines and deblocking with base. A variety of analogs demonstrated substantial activity against Plasmodium berghei infections in mice. |
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