Characterization of a novel trace-level impurity in lisinopril using multi-stage mass spectrometry |
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| Authors: | Pei Saifeng Wang Danhua Sun Cuirong Pan Yuanjiang |
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| Institution: | Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang Province 310027, China. |
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| Abstract: | An impurity in the bulk drug lisinopril was detected by simple reversed-phase high-performance liquid chromatography (HPLC). This trace-level impurity was rapidly identified as 2-(2-oxo-azocan-3-ylamino)-4-phenyl- butyric acid on the basis of the on-line multi-stage mass spectrometric evidence, and the proposed structure was further confirmed by multi-stage mass spectrometry of lisinopril and three related compounds. |
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