| 灵芝属真菌乙醇提取物抑瘤活性比较和机制探析 |
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| 引用本文： | 周月琴,杨晓彤,李绪全,糜可,冯慧琴,杨庆尧.灵芝属真菌乙醇提取物抑瘤活性比较和机制探析[J].上海师范大学学报(自然科学版),2005,34(2):77-81. |
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| 作者姓名： | 周月琴 杨晓彤 李绪全 糜可 冯慧琴 杨庆尧 |
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| 作者单位： | 上海师范大学,生命与环境科学学院,上海,200234;上海师范大学,生命与环境科学学院,上海,200234;上海师范大学,生命与环境科学学院,上海,200234;上海师范大学,生命与环境科学学院,上海,200234;上海师范大学,生命与环境科学学院,上海,200234;上海师范大学,生命与环境科学学院,上海,200234 |
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| 基金项目： | 上海市教育委员会科学项目(项目号:04DB20)
香港保健协会和上海杨杨百草研究所的资助. |
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| 摘 要： | 以人急性早幼粒白血病细胞HL-60细胞株作为模型,比较了灵芝属(Ganoderma)5 个不同种(赤芝G.lucidum,松山树芝G.tsugae,G.oerstedii,无柄灵芝G.resinaceum,G. aubamboinense)的液体培养茵丝体体外抗肿瘤活性,并初步探讨了抑瘤机制.结果显示:5个灵芝菌种的乙醇提取物对HL-60细胞均有抑制作用,其中以赤芝(G.lucidum)的抑瘤率最高(91.4±0.9%);作用48 h后,均在不同程度上诱导HL-60细胞发生早期凋亡.研究表明灵芝属的真菌除赤芝外,其他种类的发酵茵丝体醇提物也具有抑制HL-60肿瘤细胞生长的作用,抑瘤机制与诱导凋亡有关.
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| 关 键 词： | 灵芝 抗肿瘤 凋亡 HL-60 |
| 文章编号： | 1000-5137(2005)02-0077-05 |
| 修稿时间： | 2005年4月8日 |
Comparison of the anticancerous activity of ethanol extracts from fungi of Ganoderma genus and primary study of their mechanisms |
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| ZHOU Yue-qin,YANG Xiao-tong,LI Xu-quan,FENG Hui-qin,MI Ke,YANG Qing-yao.Comparison of the anticancerous activity of ethanol extracts from fungi of Ganoderma genus and primary study of their mechanisms[J].Journal of Shanghai Normal University(Natural Sciences),2005,34(2):77-81. |
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| Authors: | ZHOU Yue-qin YANG Xiao-tong LI Xu-quan FENG Hui-qin MI Ke YANG Qing-yao |
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| Abstract: | The anticancerous activities of mycelial ethanol extracts from five different species of Ganodenna (G. lucidum, G. tsugae, G. oerstedii,G. subamboinense, G. resinaceum) were studied using leukemic HL - 60 as a model cell line. The re-suits showed that all five extracts potently inhibited HL - 60 proliferation, in which the G. lueidum mycelial extract exerted the highest activity. Five extracts all significantly induced early apoptosis in HL - 60 cells, based on the results from Annexin V/PI bivariate flow cytometric assays. The results illustrate that in addition to G. lueidum , other Ganoderma species can also inhibit HL -60 cells, and the mechanism is related to induction of apoptosis. |
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| Keywords: | Ganoderma anti-proliferation apoptosis HL-60 |
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