| Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid |
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| 引用本文： | Nian Guang Li,Qi Dong You,Xue Feng Huang,Jin Xin Wang,Qing Long Guo,Xiao Guang Chen,Yan Li,Hong Yan Li Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China Department of Physiology,China Pharmaceutical University,Nanjing 210009,China Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China. Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid[J]. 中国化学快报, 2007, 18(6): 659-662. DOI: 10.1016/j.cclet.2007.04.010 |
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| 作者姓名： | Nian Guang Li Qi Dong You Xue Feng Huang Jin Xin Wang Qing Long Guo Xiao Guang Chen Yan Li Hong Yan Li Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Department of Physiology China Pharmaceutical University Nanjing 210009 China Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College Beijing 100050 China |
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| 作者单位： | Nian Guang Li，Qi Dong You，Xue Feng Huang，Jin Xin Wang，Qing Long Guo，Xiao Guang Chen，Yan Li，Hong Yan Li Department of Medicinal Chemistry，China Pharmaceutical University，Nanjing 210009，China Department of Physiology，China Pharmaceutical University，Nanjing 210009，China Institute of Materia Medica，Chinese Academy of Medical Science and Peking Union Medical College，Beijing 100050，China |
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| 基金项目： | 国家高技术研究发展计划(863计划);江苏省自然科学基金 |
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| 摘 要： | Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.
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| 收稿时间： | 2007-01-10 |
Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid |
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| Nian Guang Li,Qi Dong You,Xue Feng Huang,Jin Xin Wang,Qing Long Guo,Xiao Guang Chen,Yan Li,Hong Yan Li. Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid[J]. Chinese Chemical Letters, 2007, 18(6): 659-662. DOI: 10.1016/j.cclet.2007.04.010 |
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| Authors: | Nian Guang Li Qi Dong You Xue Feng Huang Jin Xin Wang Qing Long Guo Xiao Guang Chen Yan Li Hong Yan Li |
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| Affiliation: | 1. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;2. Department of Physiology, China Pharmaceutical University, Nanjing 210009, China;3. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities. |
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| Keywords: | Gambogic acid Small molecular compounds Antitumor activity |
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