Palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water |
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| Authors: | Wolf Christian Lerebours Rachel |
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| Affiliation: | Department of Chemistry, Georgetown University, Washington, DC 20057, USA. cw27@georgetown.edu |
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| Abstract: | A palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reaction that proceeds in water under air atmosphere in the absence of organic co-solvents has been developed. Disubstituted alkynes have been prepared in up to 91% yield by POPd-catalyzed coupling of various aryl halides including chlorides in the presence of tetrabutylammonium bromide and pyrrolidine or NaOH. |
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