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Expedient five-step synthesis of SIB-1508Y from natural nicotine |
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| Authors: | Wagner Florence F Comins Daniel L |
| Affiliation: | Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA. |
| Abstract: | Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine. |
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