| 具有抗HIV病毒活性的杂多酸HPA-23与谷胱甘肽的作用 |
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| 引用本文： | 赵大庆,高新风,吴亦洁,孝延文,裴奉奎,倪嘉缵,刘景福,刘娅.具有抗HIV病毒活性的杂多酸HPA-23与谷胱甘肽的作用[J].无机化学学报,1994,10(2):155-159. |
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| 作者姓名： | 赵大庆 高新风 吴亦洁 孝延文 裴奉奎 倪嘉缵 刘景福 刘娅 |
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| 摘 要： | 以谷胱甘肽作为病毒包络蛋白的模拟物，用ＮＭＲ方法研究了与具有抗爱滋病病毒活性杂多酸ＨＰＡ－２３的作用。对不同配比的ＨＰＡ－２３和谷胱甘肽混合物的＾１Ｈ和＾１＾８＾３ＷＮＭＲ谱研究结果表明，还原型和氧化型谷胱甘肽均以Ｃ末端ＣＯＯ＾－与ＨＰＡ－２３骨架的钨原子配位，还原型谷胱甘肽侧链上的巯基（ＳＨ）也参加配位。ＣＯＳＹ谱证明了ＳＨ配位为慢交换反应。早在七十年代初，人们就发现杂多酸具有抗病毒活性。最近报
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| 关 键 词： | 杂多酸 谷胱甘肽 HPA－23 NMR |
| 收稿时间： | 1993/3/24 0:00:00 |
INTERACTIONS OF HETEROPOLYTUNGSTATE HPA-23 WITH GLUTATHIONE STUDY BY NMR SPECTROSCOPY |
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| Zhao Daqing,Gao Xinfeng,Wu Yijie,Xiao Yanwen,Pei Fengkui,Ni Jiazan,Liu Jingfu and Liu Ya.INTERACTIONS OF HETEROPOLYTUNGSTATE HPA-23 WITH GLUTATHIONE STUDY BY NMR SPECTROSCOPY[J].Chinese Journal of Inorganic Chemistry,1994,10(2):155-159. |
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| Authors: | Zhao Daqing Gao Xinfeng Wu Yijie Xiao Yanwen Pei Fengkui Ni Jiazan Liu Jingfu and Liu Ya |
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| Abstract: | The interactions of heteropolytungstate HPA-23 known to exhibit human immunodeficiency virus with glutathione(GSH and GSSG) used as model for envelope protein of the virus have been investigated by 1H and 183W NMR spectroscopy. Both GSH and GSSG interact with atoms W in the framework of HPA-23 by the COO- group of C-termal. The SH group in the side chain of GSH is also bound to HPA-23, and this process is verified to be slowly exchange by COSY. |
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| Keywords: | NMR heteropolytungstate glutathione |
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