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Synthesis of isoindolin-1-one derivatives via multicomponent reactions of methyl 2-formylbenzoate and intramolecular amidation |
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| Authors: | Jie Lei Zhi-Gang Xu Shi-Qiang Li Jia Xu Jin Zhu Zhong-Zhu Chen |
| Affiliation: | 1.Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu,China;2.University of Chinese Academy of Sciences,Beijing,China;3.Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI,Chongqing University of Arts and Sciences,Yongchuan, Chongqing,China |
| Abstract: | Four series of heterocyclic compounds were obtained using Ugi-type multicomponent reactions (MCRs) with methyl 2-formylbenzoate as one of the starting materials. A facile and efficient one-pot procedure was suitable for all the MCRs under acidic conditions. This process provided access to four series of complex and potentially biologically active scaffolds. |
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