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Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water
Authors:Rajeev Shrestha  Kavita Sharma  Yong Rok Lee  Young-Jung Wee
Affiliation:1.School of Chemical Engineering,Yeungnam University,Gyeongsan,Republic of Korea;2.Department of Food Science and Technology,Yeungnam University,Gyeongsan,Republic of Korea
Abstract:An efficient and facile green synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved via a (mathrm{CeO}_{2})-NPs catalyzed four-component reaction in water. The protocol offers an environmentally benign and effective approach to highly functionalized and biologically interesting spiro[indoline-3,4(^prime )-pyrano[2,3-c]pyrazole] derivatives. The synthesized compounds exhibit potent antioxidant and antibacterial activities.
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