Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water |
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Authors: | Rajeev Shrestha Kavita Sharma Yong Rok Lee Young-Jung Wee |
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Affiliation: | 1.School of Chemical Engineering,Yeungnam University,Gyeongsan,Republic of Korea;2.Department of Food Science and Technology,Yeungnam University,Gyeongsan,Republic of Korea |
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Abstract: | An efficient and facile green synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved via a (mathrm{CeO}_{2})-NPs catalyzed four-component reaction in water. The protocol offers an environmentally benign and effective approach to highly functionalized and biologically interesting spiro[indoline-3,4(^prime )-pyrano[2,3-c]pyrazole] derivatives. The synthesized compounds exhibit potent antioxidant and antibacterial activities. |
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