Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard |
| |
| Authors: | H Cheloufi B Belhani T S Ouk R Zerrouki N-E Aouf M Berredjem |
| |
| Institution: | 1.Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar,Annaba University,Annaba,Algeria;2.Laboratoire de Chimie des Substances Naturelles,Université de Limoges,Limoges Cedex,France |
| |
| Abstract: | A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a–m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
