High performance liquid chromatography method for the determination of meropenem in human plasma |
| |
Authors: | D Farin R Kitzes-Cohen G Piva I Gozlan |
| |
Institution: | (1) Clinical Pharmacology and Infectious Diseases Unit, Carmel Medical Center, The Rappaport Faculty of Medicine, Technion, 7 Michal St., 34362 Haifa, Israel |
| |
Abstract: | Summary This paper describes an HPLC method for the determination of meropenem in human plasma. The method uses solid phase extraction
(SPE) of the samples and has good sensitivity, precision and accuracy. The limit of quantification in plasma samples is 0.02
μg mL−1. Calibration curves were linear over a large dynamic range, namely within 0.02–50 μg mL−1. The method was applied to the determination of meropenem levels in patients receiving meropenem, as a single dose or at
steady state. |
| |
Keywords: | Column liquid chromatography Meropenem in human plasma Solid phase extraction |
本文献已被 SpringerLink 等数据库收录! |
|