Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3 |
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| Authors: | Giguère Denis Patnam Ramesh Bellefleur Marc-André St-Pierre Christian Sato Sachiko Roy René |
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| Institution: | Department of Chemistry, Université du Québec à Montréal, P.O. Box 8888, Succ. Centre-Ville Montreal, Que., Canada H3C 3P8. |
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| Abstract: | Galactosides and lactosides bearing triazoles or isoxazoles, regiospecifically prepared by 1,3]-dipolar cycloadditions between alkynes, azides or nitrile oxides, provided specific galectin-1 and -3 inhibitors with potencies as low as 20 microM. |
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