Abstract: | We present a determination of the Cabibbo-Kobayashi-Maskawa matrix element |Vub| based on the analysis of semileptonic B decays from a sample of 88 x 10(6) Gamma(4S) decays collected with the BABAR detector at the SLAC PEP-II e+e- storage ring. Charmless semileptonic B decays are selected using measurements of the electron energy and the invariant mass squared of the electron-neutrino pair. We obtain |Vub| =(3.95 +/- 0.26(+0.58)(-0.42) +/- 0.25) x 10(-3), where the errors represent experimental uncertainties, heavy quark parameter uncertainties, and theoretical uncertainties, respectively. |