1.College of Chemistry and Materials Science,Anhui Normal University,Wuhu,People’s Republic of China;2.Key Laboratory for Functional Molecular Solids of the Education Ministry of China,Wuhu,People’s Republic of China;3.Anhui Key Laboratory of Chem-Biosensing,Anhui Normal University,Wuhu,People’s Republic of China
Abstract:
This article reviews the progress made in the past 5 years in the field of direct and non-enzymatic electrochemical sensing of glucose. Following a brief discussion of the merits and limitations of enzymatic glucose sensors, we discuss the history of unraveling the mechanism of direct oxidation of glucose and theories of non-enzymatic electrocatalysis. We then review non-enzymatic glucose electrodes based on the use of the metals platinum, gold, nickel, copper, of alloys and bimetals, of carbon materials (including graphene and graphene-based composites), and of metal-metal oxides and layered double hydroxides. This review contains more than 200 refs.
Figure This article reviews the history of unraveling the mechanism of direct electrochemical glucose oxidation and the attempts to successfully develop non-enzymatic electrochemical glucose sensors over the past 5 years.
