| 常规T2像和组织学研究APPswe/PS1dE9转基因小鼠模型 |
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| 引用本文： | 徐威,湛颜强.常规T2像和组织学研究APPswe/PS1dE9转基因小鼠模型[J].波谱学杂志,2011,28(1):127-134. |
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| 作者姓名： | 徐威 湛颜强 |
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| 作者单位： | 波谱与原子分子物理国家重点实验室(中国科学院武汉物理与数学研究所),湖北武汉,430071;华中科技大学同济医学院附属同济医院神经科,湖北武汉,430030 |
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| 基金项目： | 国家重点基础研究发展计划(“973”计划)资助项目(2006CB705600); 国家自然科学基金资助项目(30870674,20921004) |
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| 摘 要： | 用常规的T2加权像研究阿尔茨海默病双转基因APPswe/PS1dE9小鼠模型,拟合了海马和顶叶皮层的T2,并用组织学方法研究了APP/PS1小鼠在这2个感兴趣区域随年龄相关的淀粉样斑块病理的发展及铁质的沉积. T2拟合的结果显示,较高月龄的APP/PS1小鼠相比于低月龄APP/PS1小鼠T2有升高但不显著,各月龄组APP/PS1小鼠与同窝生非阳性小鼠之间也无明显差异;组织学的结果则显示年龄相关的淀粉样斑块的增多,铁质在16月龄的APP/PS1小鼠脑区中有明显沉积且和斑块具有“共域性”. 两方面的实验结果提示：在该模型淀粉样斑块沉积病理发展的早期,这2个脑区的T2并不能作为特异性的病理发展的标志.
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| 关 键 词： | 磁共振成像(MRI) T2加权像 淀粉样斑块 铁质沉积 阿尔茨海默病 |
T2-Weighted Imaging and Histological Assessment on a Transgenic APPswe/PSldE9 Mouse Model |
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| XU Wei,ZHAN Yan-qiang.T2-Weighted Imaging and Histological Assessment on a Transgenic APPswe/PSldE9 Mouse Model[J].Chinese Journal of Magnetic Resonance,2011,28(1):127-134. |
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| Authors: | XU Wei ZHAN Yan-qiang |
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| Institution: | 1. State Key Laboratory of Magnetic Resonance and Molecular and Atomic Physics, (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;;
2. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | We studied a double transgenic APPSwe/PS1dE9 mouse model using T2-weighted imaging and histological assessment to detect age-related amyloidosis and iron load in the hippocampus and cortex.The results indicated that T2 of older transgenic mice was slightly higher than that of the younger ones,but the difference did not reach statistical significance.We also did not found any significant T2 difference between transgenic mice and age-matched non-transgenic littermates.Histological assessment revealed an age-r... |
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| Keywords: | MRI " target="_blank">T2-weighted imagingzz')" href="#"> T2-weighted imaging amyloid-β iron load Alzheimer’s disease |
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