The determination of alendronate ion and certain inorganic ions using capillary electrophoresis |
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| Authors: | E. P. Svidritskii M. Sh. Jiang V. I. Il’in D. I. Dyn’kov A. V. Pirogov O. A. Shpigun |
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| Affiliation: | (1) North Carolina A&T State University, Greensboro, NC, USA;(2) Department of Family and Consumer Sciences, North Carolina A&T State University, 27411-1064 Greensboro, NC, USA;(3) Department of Natural Resources and Environmental Design, North Carolina A&T State University, 27411-1064 Greensboro, NC, USA;(4) Southern Illinois University, Carbondale, IL, USA;(5) National Research Center, Dokki, Cairo, Egypt; |
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| Abstract: | A procedure for simultaneous determination of alendronate, chloride, phosphite, phosphate, and methylsulphonate anions is proposed. These ions are the main admixtures in synthetic alendronic acid, and their content should be controlled when producing pharmaceutical preparations of alendronic acid. The developed method makes it possible to determine all the indicated ions over a period of 4 min. Excellent efficiency (200000–500000 theoretical plates) makes it possible to determine ions even with a high content of one of the components. The detection limits are 0.4−2.3 mg/l. The developed method has been successfully applied for the analysis of methanesulfonic acid regenerated from the reaction mixture. |
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