Chelating behavior, thermal studies and biocidal efficiency of tioconazole and its complexes with some transition metal ions |
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| Authors: | Hanan F. Abd El-Halim F. A. Nour El-Dien Gehad G. Mohamed Nehad A. Mohamed |
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| Affiliation: | 1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt
2. Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt
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| Abstract: | New seven metal complexes of tioconazole drug with the general formulae [MCl2(L)2(H2O)x].yH2O (where, x = 0 and y = 1 for M = Mn(II) or x = 2, y = 2 for M = Co(II)), and x = 0, y = 3 for M = Cu(II), Ni(II), Zn(II)) and [MCl2(L)2(H2O)2]Cl.3H2O (where M = Cr(III) and Fe(III)) have been prepared and characterized based on elemental analyses, IR, magnetic moment, molar conductance, and thermal analyses techniques. From molar conductance data bivalent metal chelates are non-electrolytes while Cr(III) and Fe(III) chelates are electrolytes and of 1:1 type. According to the IR spectral data, TCNZ is coordinated to the metal ions in a neutral unidentate manner with N donor site of the imidazole–N. All the complexes are octahedral except Mn(II) complex has tetrahedral structure. TCNZ drug and its metal complexes were also screened for their biological activity. |
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