Crystal habit modifications of imatinib mesylate under various precipitation conditions |
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| Authors: | Miroslav Veverka Peter ?imon Ján Lokaj Eva Veverková |
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| Affiliation: | (1) Research and Development Department, Bel/Novamann Ltd., 820 04 Bratislava, Slovakia;(2) Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinsk?ho 9, 812 37 Bratislava, Slovakia;(3) Faculty of Material Science and Technology, Slovak University of Technology, 917 24 Trnava, Slovakia;(4) Faculty of Natural Sciences, Comenius University, 842 15 Bratislava, Slovakia; |
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| Abstract: | Abstract Crystals of the α-form of imatinib mesylate with various habits (e.g., polyhedral-like and plate-like) were prepared from various organic solvents (e.g., butyl lactate, 4-methyl-2-pentanone, 2-methyl-2-butanol, 2-isopropoxyethanol, propyl ether) by several precipitation methods. The methods provide imatinib mesylate in a non-needle-shaped crystalline α-form. The crystal modification was identified by hot-stage microscopy, scanning electron microscopy, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRPD). The analyses by DSC, IR, and XRPD indicate that imatinib mesylate crystals with various habits have the same crystal structure. The plate-like habit has been also observed in the system where the organic solvent acts as a precipitant. |
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