Effects of the ancillary ligands of polypyridyl cobalt(II) complexes on pH-induced spectral properties and DNA binding properties |
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| Authors: | Xian W Huang Wen T Zhu Jia C Zhang and Guo J Su |
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| Institution: | (1) College of Chemistry, Xiangtan University, Xiangtan, 411105, People’s Republic of China;(2) Universtar Science & Technology (Shenzhen) Co., Ltd., Shenzhen, People’s Republic of China; |
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| Abstract: | Abstract Two new Co(II) complexes Co(ipH)2(bdipH)]2+ and Co(8-HQ)2(bdipH)] (ipH = imidazo4,5-f]1,10]phenanthroline, bdipH = 2-(benzod]1,3]dioxol-4-yl)-1H-imidazo4,5-f]1,10]phenanthroline, 8-HQ = 8-hydroxyquinoline) were synthesized and characterized in detail by elemental analysis, IR,
and UV–Vis spectroscopic techniques. The effects of pH on the UV–Vis absorption and emission spectra of the complex were studied.
The interaction of the two complexes with calf thymus DNA was explored by using viscosity measurements, electronic absorption
titration, competitive binding experiments, and cyclic voltammetry. The experimental results show that complex Co(ipH)2(bdipH)]2+ exhibits pH-sensitive emission, the two complexes can bind to DNA in an intercalation mode, and the DNA binding affinity
of complex Co(ipH)2(bdipH)]2+ (K
b = 2.11 × 105 M−1) is greater than that of complex Co(8-HQ)2(bdipH)] (K
b = 1.76 × 105 M−1). The results show that the size and shape of the ancillary ligand have significant effects on the binding affinity of DNA
and complexes. |
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