| 3-氨基-5-取代苯氨基-6-苯基-1,2,4-三嗪的合成 |
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| 引用本文： | 陆忠娥,万军,陈克潜. 3-氨基-5-取代苯氨基-6-苯基-1,2,4-三嗪的合成[J]. 有机化学, 1992, 12(6): 605-607 |
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| 作者姓名： | 陆忠娥 万军 陈克潜 |
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| 作者单位： | 苏州大学化学系，苏州大学化学系，苏州大学化学系 江苏，苏州，215006，江苏，苏州，215006，江苏，苏州，215006 |
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| 摘 要： | 3-氨基-1,2,4-三嗪化合物具有广泛的生理活性,如:治疗支气管扩张、抑制乳酸菌和症原虫繁殖杀菌等,因此,研究这类化合物合成方法应运而生。本文以苯甲酰基硫代甲酰胺为原料,进一步合成了氨基-5-取代苯氨基-6-苯基-1,2,4-三嗪。
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| 关 键 词： | 苯胺 P 氨基胍 P 苯 P 三嗪 P 三嗪胺 P 支气管扩张 硫代甲酰胺 杀菌性 |
Synthesis of 3-amino-5-substituted phenylamino-6- phenyl- 1, 2, 4 -triazines |
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| LU Zhong-E,WAN Jun,CHEN Ke-Qian. Synthesis of 3-amino-5-substituted phenylamino-6- phenyl- 1, 2, 4 -triazines[J]. Chinese Journal of Organic Chemistry, 1992, 12(6): 605-607 |
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| Authors: | LU Zhong-E WAN Jun CHEN Ke-Qian |
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| Affiliation: | LU Zhong-E,WAN Jun,CHEN Ke-Qian Department of Chemistry,Suzhou University,215006 Suzhou,Jiangsu |
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| Abstract: | A new synthetic method of 3-amino-5-substituted phenylamino-6-phenyl-1,2,4-triazines was reported. Benzoylthioformanilides were first condensed with aminoguanidine dihydrochloride in slightly acidic medium, then refluxed in alkaline medium (pH 8~9) to give title compounds by the elimination of hydrogen sulfide. Nine 1,2,4-triazines I (R = Ph, substituted Ph) were synthesized by this reaction in good yields. |
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| Keywords: | benzoyl thioformanilide aminoguanidine 3-amino-1 2 4-triazine |
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